Abstract:
Hyperthermic intraperitoneal chemotherapy is a popular method of
palliative treatment in patients with malignant abdominal tumors. This
review is devoted to trace changes in general clinical tests in patients with
carcinomatosis. The patients were operated on at the Clinic of Reconstructive
and Plastic Medicine of the Odessa National Medical University. All patients
satisfactorily tolerated this procedure. The object of the study was to track
those changes with patients that took place in the immediate (prior to
discharge) postoperative period. 25 patients have recruited to the study. In
the group changes in 11 basic clinical and laboratory parameters among those
included were monitored in the study. Hemoglobin, leukocytes, platelets,
total protein, bilirubin, serum glucose concentration, liver enzymes alanine
aminotransferase and aspartate aminotransferase levels, thymol test and
coagulogram indices. Thus, the most significant indicators, such as the
concentration of hemoglobin, leukocytes and platelets, have not undergone
significant changes after HIPEC. Hemoglobin decreased by 6 units (g / l), the
concentration of leukocytes, on the contrary, increased by 2 units (T/l),
platelet levels dropped by 61 units (also G/l). The concentration of total
protein decreased by 7 units. The concentration of total bilirubin practically
did not change, decreasing by about 1 unit. Indicators of AST and ALT did
not increase, decreasing by 8 and 3 units, respectively. The average
concentration value of blood glucose level slightly increased by almost 1
unit. Thymol levels have not changed. The prothrombin index decreased by 3
units; the concentration of fibrinogen in serum remained at approximately the
same level. HIPEC procedure does not significantly affect the clinical and
laboratory parameters. However, the tendency of this category of patients to
hypercoagulation, hypoproteinemia and hyperglucosemia was noted.
