Короткий опис (реферат):
The aim. To determine the distribution features of various forms of Helicobacter pylori infection and
their concentration on the gastric mucosa in various topographic zones in patients with chronic
atrophic gastritis, suffering from chronic constipation.
Materials and methods. A comprehensive examination of 100 patients with chronic non-atrophic
gastritis was carried out, of which 50 patients suffered from chronic constipation (main group), and 50
patients did not suffer from constipation (control group), in which the presence of various forms was
determined, as well as the degree of colonization of Helicobacter pylori infection in various
topographic zones of the stomach.
Results. When analyzing the results, it was found that in the group of patients suffering from
chronic constipation, the frequency of occurrence of the active form of Helicobacter pylori infection in
different topographic zones of the stomach ranged from 46% to 56% with an average degree of
mucosal colonization of 1.12 ± 0.13 (+) up to 1.48 ± 0.13 (+), the frequency of occurrence of an inactive
form of Helicobacter pylori infection in different topographic zones of the stomach ranged from 0% to
48% with an average degree of mucosal colonization from 0 ± 0.0 (+) to 1.30 ± 0.13 (+), while while in
the group of patients who did not suffer from chronic constipation, the frequency of occurrence of a n
act distinct Helicobacter pylori infection in different topographic zones of the stomach ranged from
36% to 52% with an average degree of mucosal seeding from 1.02 ± 0.13 (+) to 1.34 ± 0.13 (+), and the
frequency of occurrence of the inactive Helicobacter pylori infections in different topographic zones of
the stomach ranged from 0% to 58% with an average degree of mucosal seeding from 0 ± 0.0 (+) to 1.56
± 0.13 (+).In patients of the first group, the frequency of detection of intracellular "depots" of HP
infection was 2.3 times higher than in patients of the second group.
Conclusions. In patients with chronic non-atrophic gastritis, suffering from chronic constipation, the
degree of contamination of the gastric mucosa with active forms of HP infection is significantly higher
in the body of the stomach by a large curvature than in patients with chronic non-atrophic gastritis who
do not suffer from constipation. The frequency of detection of intracellular "depots" of HP infection in
patients with chronic non-atrophic gastritis, suffering from chronic constipation, is 2.3 times higher
than in patients with chronic non-atrophic gastritis who do not suffer from constipation, which indicates a longer and more common pathological process the effect of HP infection on the
digestive process, in which the intestines are also involved.
All human studies were conducted in compliance with the rules of the Helsinki Declaration of the
World Medical Association "Ethical principles of medical research with human participation as an object
of study". Informed consent was obtained from all participants.
