Features of the distribution of the concentration on the mucous stomach of active and inactive forms of helicobacterial infection in patients with chronic non-atrophic gastritis, suffering and not suffering from chronic constipation

Abstract

The aim. To determine the distribution features of various forms of Helicobacter pylori infection and their concentration on the gastric mucosa in various topographic zones in patients with chronic atrophic gastritis, suffering from chronic constipation. Materials and methods. A comprehensive examination of 100 patients with chronic non-atrophic gastritis was carried out, of which 50 patients suffered from chronic constipation (main group), and 50 patients did not suffer from constipation (control group), in which the presence of various forms was determined, as well as the degree of colonization of Helicobacter pylori infection in various topographic zones of the stomach. Results. When analyzing the results, it was found that in the group of patients suffering from chronic constipation, the frequency of occurrence of the active form of Helicobacter pylori infection in different topographic zones of the stomach ranged from 46% to 56% with an average degree of mucosal colonization of 1.12 ± 0.13 (+) up to 1.48 ± 0.13 (+), the frequency of occurrence of an inactive form of Helicobacter pylori infection in different topographic zones of the stomach ranged from 0% to 48% with an average degree of mucosal colonization from 0 ± 0.0 (+) to 1.30 ± 0.13 (+), while while in the group of patients who did not suffer from chronic constipation, the frequency of occurrence of a n act distinct Helicobacter pylori infection in different topographic zones of the stomach ranged from 36% to 52% with an average degree of mucosal seeding from 1.02 ± 0.13 (+) to 1.34 ± 0.13 (+), and the frequency of occurrence of the inactive Helicobacter pylori infections in different topographic zones of the stomach ranged from 0% to 58% with an average degree of mucosal seeding from 0 ± 0.0 (+) to 1.56 ± 0.13 (+).In patients of the first group, the frequency of detection of intracellular "depots" of HP infection was 2.3 times higher than in patients of the second group. Conclusions. In patients with chronic non-atrophic gastritis, suffering from chronic constipation, the degree of contamination of the gastric mucosa with active forms of HP infection is significantly higher in the body of the stomach by a large curvature than in patients with chronic non-atrophic gastritis who do not suffer from constipation. The frequency of detection of intracellular "depots" of HP infection in patients with chronic non-atrophic gastritis, suffering from chronic constipation, is 2.3 times higher than in patients with chronic non-atrophic gastritis who do not suffer from constipation, which indicates a longer and more common pathological process the effect of HP infection on the digestive process, in which the intestines are also involved. All human studies were conducted in compliance with the rules of the Helsinki Declaration of the World Medical Association "Ethical principles of medical research with human participation as an object of study". Informed consent was obtained from all participants.