Abstract:
Recently it has been established that cytokines are involved in the regulation of the
body’s defense reactions in response to a pathogen and form an independent system for
regulating homeostasis. The aim of this work is to study the relationship of the polymorphic
marker TNFα (rs1800620) with its quantitative content and the degree of liver fibrosis in
patients with various chronic hepatitis (VHC, VHB, VHB+C). The 82 patients with chronic
hepatitis B, 62 patients with hepatitis B+C, and 100 patients with chronic hepatitis C were
examined. GGTNFα (rs1800620) genotype is protective for patients with various viral
hepatitis, and the GATNFα (rs1800620)and AATNFα (rs1800620)genotypes are profibrogenic
for patients with chronic hepatitis B, chronic hepatitis B+C and chronic hepatitis C,
respectively, since a high degree of fibrosis than in carriers of the homozygous GGTNFα
(rs1800620)genotype. It is possible that the rate of fibrosis progression is influenced not only by the qualitative content of TNFα, but also by a certain genotype.
