Abstract:
Proved development of endothelial dysfunction in rats that was modeled experimental diabetic
retinopathy, as evidenced by increased endothelin-1 levels. It was found that at each stage of the study,
pathological vasoconstriction increases (p <0.001 compared with the intact group). It was revealed that
simulated diabetic retinopathy negatively affects vasodilation potential, as evidenced by the analysis of
the content of S-nitrosothiols in the blood of experimental animals (p <0.001 compared with the data
of intact animals). In the analysis of vasoconstrictor-vasodilyatatsiynogo potential at each stage of the
experiment proved the prevalence of pathological vasoconstriction (p <0.001).
The weakening of the vasodilatory potential was step by step more gradual in comparison w ith the
dynamics of the increase in the vasodilation potential. In a comparative experiment characteristic
pathological stages most pronounced shifts mounted on stage III of diabetic retinopathy study
simulated (180-day).
