Abstract:
The investigation of proliferation markers expression Кі67 and apoptosis p53, bcl-2 in endometrial hyperplastic processes (EHP). Methods Data of 66 women endometrial tissue samples (mean age 47,3±4,5 years) were investigated: 52 with EHP and 14 healthy biphasic. According to proliferative processes differentiation 5 groups were obtained: 1 - simple hyperplasia without atypical cells-11 women; II – complex hyperplasia without atypical cells–18; III – simple hyperplasia with atypical cells-10; IV - complex hyperplasia with atypical cells –13 patients; V - control group morphologically unchanged endometrium–14. Immune hystochemical reactions with antibodies to Кі67, bcl2, p53 (DAKO-Germany) were used.
