Особенности микробиоценоза кишечника у беременных с метаболическим синдромом, у которых состоялись преждевременные роды

Abstract

The state of intestinal microbiocenosis in 72 patients with diagnosed metabolic syndrome (MS) at the background of premature births has been investigated. Depending on the gestation period by the time of delivery (22-27 weeks, 28-33 weeks, 34-36 weeks), pregnant women were divided into three subgroups. The majority of the women under examination had different complications of pregnancy since the early gestation. Among them there were the threat of interruption of pregnancy in the first trimester ( 81.9% of cases), vomiting of varying severity (62.5%), non severe degree of pre-eclampsia ( 26.4%), severe pre-eclampsia ( (11.1%), premature detachment of the normally located placenta (5.6%), delayed fetal development ( 91.7%), fetal distress ( 4.2%). Births through natural birth canals occurred in 79.2% of cases, operative delivery by cesarean section due to complications of pregnancy was conducted in 20.8% of cases. In the bacteriological study of feces in women with MS and preterm labor, a clear violation of the microecology of the intestine was revealed, characterized by a significant decrease in the content of the main representatives of the obligate microflora (Bifidobacterium, Lacto bacillus, Escherichia coli, Foecal streptococci) and the growth of opportunistic bacteria such as Proteus, Klebsiella, pathogenic strains of E. coli, Staphylococcus epidermidis, and especially Candida albicans. The intestinal dysbiosis, accompanied by a significant decrease in the indigenous microflora and simultaneous high contamination of Candida albicans, can be considered as a predictor of premature birth in MS women. The prevention of dysbiotic disorders and timely sanation of the intestine is quite possible to reduce the frequency of preterm labor in pregnant women with MS, therefore further study of this direction is promising and pathogenetically justified.