Abstract:
The state of intestinal microbiocenosis in 72 patients with diagnosed metabolic
syndrome (MS) at the background of premature births has been investigated. Depending on
the gestation period by the time of delivery (22-27 weeks, 28-33 weeks, 34-36 weeks), pregnant
women were divided into three subgroups. The majority of the women under examination had
different complications of pregnancy since the early gestation. Among them there were the threat
of interruption of pregnancy in the first trimester ( 81.9% of cases), vomiting of varying severity
(62.5%), non severe degree of pre-eclampsia ( 26.4%), severe pre-eclampsia ( (11.1%), premature
detachment of the normally located placenta (5.6%), delayed fetal development ( 91.7%), fetal
distress ( 4.2%). Births through natural birth canals occurred in 79.2% of cases, operative
delivery by cesarean section due to complications of pregnancy was conducted in 20.8% of cases.
In the bacteriological study of feces in women with MS and preterm labor, a clear violation of the
microecology of the intestine was revealed, characterized by a significant decrease in the content of
the main representatives of the obligate microflora (Bifidobacterium, Lacto bacillus, Escherichia
coli, Foecal streptococci) and the growth of opportunistic bacteria such as Proteus, Klebsiella,
pathogenic strains of E. coli, Staphylococcus epidermidis, and especially Candida albicans.
The intestinal dysbiosis, accompanied by a significant decrease in the indigenous microflora
and simultaneous high contamination of Candida albicans, can be considered as a predictor of
premature birth in MS women. The prevention of dysbiotic disorders and timely sanation of the
intestine is quite possible to reduce the frequency of preterm labor in pregnant women with MS,
therefore further study of this direction is promising and pathogenetically justified.
