Метою даного дослідження є оцінка функціонального стану судинно – тромбоцитарної, коагуляційної ланки і фібринолізу системи гемостазу та їх розладів за допомогою низькочастотної вібраційної п’єзоелектричної
тромбоеластографії (НПТЕГ) у хворих на облітеруючий атеросклероз нижніх кінцівок на фоні лікування.
Relevance. Along with the problem of cardiovascular disease in recent years, there
is an increased interest in angiology, due to the prevalence among the population of
diseases with violation of peripheral circulation.
Objective of the study. The purpose of this study is to evaluate the functional
state of the vascular – platelet, coagulation and fibrinolysis of the hemostasis
system and their disorders with the help of low – frequency vibration piezoelectric
thromboelastography (NPTEG) in patients with obliterating atherosclerosis of the
lower extremities on the background of treatment.
Materials and methods. The initial state of the hemostatic system in 45 patients
treated for obliterating atherosclerosis of the lower extremities at the Odessa
Regional Clinical Hospital was assessed. During surgery and in the postoperative
period, patients received analgesia based on epidural administration of bupivacaine,
and they also included 15 mg rivaroxoban 2 times a day from the first postoperative
days. The dynamics of the hemostatic system in this group of patients was assessed
using low-frequency piezoelectric thromboelastography (NPTEG) on the first day
prior to surgery, and on days 3, 5 and 7 after.
Results. The results of the study indicate that in patients with obliterating
atherosclerosis of the lower extremities, there are pronounced disorders of the
aggregative state of the blood, where hypercoagulation dominates the anticoagulant
potential. During treatment with epidural administration of bupivacaine,
rivaroxaban 15 mg, 2 times a day, from the first postoperative day, significant
changes were observed towards normalization in all components of the hemostasis
system using the method of NPTEG (p <0.001). This indicates the effectiveness of
intensive care using rivaroxaban against the background of a systemic pathological
process, the normalization of hemostasis system indicators in patients with
obliterating atherosclerosis of the lower extremities.
