Regulation of the Contractile Activity of the Small Intestine Isolated Segment in Vitro

Abstract

Radical cystectomy with urine derivation in the segment of the small intestine is the "gold standard" for the treatment of muscle-invasive bladder cancer. The main method of urine derivation, providing the best quality of life for the patient, is an orthotopic bladder formed from the ileal segment of the intestine. The aim of study was to examine the effect of new chemical compounds on the contractile activity of the ileal wall of mini-pigs in vitro. Pyrrole-2-carbaldehyde 3-(dimethylamino) benzoylhydrazone and 1-methylisatin N, N-dimethylcarbamylhydrazone are two compounds with the greatest constrictor activity. Such compounds in concentration of 1×10-3 mol / l, increase the contractile activity on 54.3 ± 9.2% and 51.2 ± 3.1%, the amplitude of contractions on 59.01 ± 12%, and 49.18 ± 14%, the frequency of reductions on 47.9 ± 6.4 % and 31.3 ± 5.3%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone reduce hypertonicity on 49.6 ± 3.8% and respectively on 39.6% ± 3.1%. Pyrrole-2-carbaldehyde 2-hydroxybenzoylhydrazone and isatin benzoylhydrazone are the two compounds that reduce hypertonicity on 49.6 ± 3.8% and 39.6% ± 3.1%, making antispasmodic effect with tropicity to ileum.