Abstract:
The purpose of the research was the identification of association of organs and
systems damage in Sjogren’s syndrome with the presence of organ-specific and organnonspecific autoantibodies.
On the basis of complex examination of 21 patients with Sjogren’s syndrome (women
age 53,5 ± 0,9 years old) and content determination of wide spectrum of organ-specific and
organ-nonspecific autoantibodies we estimated the existence of association between presence
of these autoantibodies and clinical manifestations of Sjogren’s syndrome. The received
results demonstrate the relationship between the expressiveness of inflammatory
manifestations and the content of antibodies to DNA. The expressiveness of salivary glands
injuries is associated with content of autoantibodies to salivary glands. The presence of associated diseases is also associated with existence of particular autoantibodies. As in all
examined patients with Sjogren’s syndrome was present the digestive tract pathology, it can
be assumed that changes in digestive tract wall lead to damage of immune system structures
and polyclonal uncontrollable activation of antibodies production.
