Abstract:
The immunological and biochemical changes caused by pregnancy may uncover new
aspects of immune tolerance, applicable in physiological and pathological contexts, and show
up new therapeutic strategies for improving pregnancy outcomes. Isoimmune conflict in
pregnancy is primarily related to the risk of pre-natal fetal death caused by massive hemolysis
when incompatible with Rh and / or AB0 antigens. The objective: The objective: to evaluate
the role of redox homeostasis in the formation of the immune response in isoimmune conflict
during pregnancy. Results. The results obtained indicate the activation of T- and Blymphocytes, which may be explained by the activation of cytokines IL-1, IL-6, IL-10. In
pregnancy isoimmune conflict moderate metabolic acidosis is observed with a predominance
of the lactic acid component and the depletion of buffer reserves. Conclusions. Isoimmune
conflict leads to moderate formation of oxidative stress, that can be described as violation of
redox-homeostasis, which in turn can be a consequence of cytotoxic reactions.
