Пін – передрак передміхурової залози патогенетичне обгрунтування моніторингу хворих

Abstract

A large attention is given to the study of certain features of the precancerous and early stages of carcinogenesis in prostate cancer. The proliferative inflammatory atrophy (PIA) and prostatic intraepithelial neoplasia (PIN) are considered as preneoplastic process characterized by pathological changes in the epithelium of prostate gland. The success and effectiveness of the treatment are depended on the on the timely performed complex of diagnostic procedures. The early diagnosis and timely treatment are the most effective way to reduce the morbidity and mortality from prostate cancer. The experimental model was built on 159 male Wistar rats with age 3 mounth, weight 150± 20 g, which were kept in standard laboratory biological clinics Odessa National Medical University. Experimental PIN model is original, developed by us and protected by a patent for an invention (pat. № 20 of 27/10/2008) and performed by subcutaneous injection of sinestrol and testosterone propionate hormones...