Короткий опис (реферат):
Aim. To investigate the effect of “mild” stress on the state of proteolysis in the oral
mucosa (OM).
Methods. Rats were subjected to “mild” stress by holding them at −20 °C for 5
minutes. In the OM, in blood serum, liver, kidneys and pancreas, proteolysis activity was
determined by the rate of hydrolysis of two substrates: casein and BAEE (benzoyl-arginine
ethyl ether).
Results. It has been established that OM has a high proteolytic activity, which begins
to decrease already 5 hours after stress. In blood serum, on the contrary, the activity of
proteolysis (substrate casein) increases after stress. The activity of BAEE-esterase does not
change significantly after stress. Conclusion. The level of proteolysis in OM is several times higher than the
corresponding indicator for blood serum and rat liver. "Mild" stress causes an increase in the
level of proteolysis in the blood serum as early as 5 hours after stress, while the level of
proteolysis in the OM after stress tends to decrease. Activation of proteolysis in the blood
after stress requires antiprotease actions using protease inhibitors.
