Enzymatic method for determining in vivo the mineralizing efficiency of osteoprotective drugs

Levitsky, A. P.; Pavlenko, K. V.; Selivanska, I. О.; Lapinska, A. P.

dc.contributor.author	Levitsky, A. P.	en
dc.contributor.author	Pavlenko, K. V.	en
dc.contributor.author	Selivanska, I. О.	en
dc.contributor.author	Lapinska, A. P.	en
dc.date.accessioned	2026-01-13T10:30:31Z
dc.date.available	2026-01-13T10:30:31Z
dc.date.issued	2026
dc.identifier.citation	Levitsky A. P., Pavlenko K. V., Selivanska I. О., Lapinska A. P. Enzymatic method for determining in vivo the mineralizing efficiency of osteoprotective drugs // Journal of Education, Health and Sport. 2026.Vol. 87. P. 1–5.	en
dc.identifier.uri	https://repo.odmu.edu.ua:443/xmlui/handle/123456789/19039
dc.description.abstract	For screening osteoprotectors, it is proposed to investigate the mineralizing activity of rat bone tissue (femur, jaws, teeth) in which experimental osteoporosis was reproduced (stress, inadequate nutrition, dysmetabolic syndrome). It is proposed to determine the mineralizing activity by the ratio of alkaline (ALP) and acid (AP) phosphatase activity in bone tissue. It is proposed to determine in vivo the mineralizing efficiency of the drug by the percentage increase in mineralizing activity per dose of the drug in mg/kg of live weight. Of the three osteoprotectors studied (EkSoVit, quercetin and ascorbic acid), quercetin was the most effective, and ascorbic acid was the least effective.	en
dc.language.iso	en	en
dc.subject	osteogenesis	en
dc.subject	mineralization	en
dc.subject	osteoprotectors	en
dc.title	Enzymatic method for determining in vivo the mineralizing efficiency of osteoprotective drugs	en
dc.type	Article	en