Structural and functional kidneys changes in experimental chronic hyperglycemia in rats

Abstract

The article is presents results of the structural and functional changes in kidney at the condition of chronic hyperglycemia. It was established that in the condition of experimental streptozotocin diabetes and microvascular complications on the background of diabetes, there was an increase in urinary protein excretion and creatinine clearance, minor changes in glomerular filtration and tubular reabsorption. In both type 2 diabetes and DN, significant changes in the urinary excretion of sodium and potassium ions were observed, which is associated with a decrease in the reabsorption of these cations in the renal tubules. To confirm the DN performed a morphological study of kidney tissue. It was found that in the group of animals with DN on the background of type 2 diabetes there was a decrease in the size of renal corpuscles with dystrophic altered cells of the outer and inner walls of the glomerular capsule, focal thickening of BM capillaries, expansion of the mesangium.