Короткий опис (реферат):
The article is presents results of the structural and functional changes in kidney at the
condition of chronic hyperglycemia. It was established that in the condition of experimental
streptozotocin diabetes and microvascular complications on the background of diabetes, there
was an increase in urinary protein excretion and creatinine clearance, minor changes in
glomerular filtration and tubular reabsorption. In both type 2 diabetes and DN, significant
changes in the urinary excretion of sodium and potassium ions were observed, which is
associated with a decrease in the reabsorption of these cations in the renal tubules. To confirm
the DN performed a morphological study of kidney tissue. It was found that in the group of
animals with DN on the background of type 2 diabetes there was a decrease in the size of renal
corpuscles with dystrophic altered cells of the outer and inner walls of the glomerular capsule,
focal thickening of BM capillaries, expansion of the mesangium.
