Experimental substantiation of the expediency of using hyperosmolar colloidal solutions for the correction of renal dysfunction in conditions of thermal skin damage

Abstract

Objective. To study the effectiveness of hyperosmolar colloidal solutions of lactoprotein with sorbitol and HAES–LX 5% on changes in renal functional activity in the dynamics of thermal skin damage. Materials and methods. The study was conducted under conditions of a chronic experiment on a model of skin burn injury. The concentration of lipoperoxidation intermediates and the activity of antioxidant enzymes in kidney homogenates was determined 1, 3, 7, 14, 21 and 30 days after thermal skin burn. The functional activity of the kidneys was determined using the model of induced water diuresis. Results. We have demonstrated marked impairment of filtration, excretory and detoxification functions of the kidneys within 30 days of the post–burn period, as well as acceleration of lipoperoxidation and inhibition of antioxidant defence activity. The saline solution had no thermoprotective effect in the skin burn model. The use of hyperosmolar colloidal solutions of lactoprotein with sorbitol and HAES–LX 5% effectively prevented the free radical mechanism of nephrocyte damage and activation of the enzymatic link of antioxidant defence. The optimum protective activity of the hyperosmolar colloidal solutions of lactoprotein with sorbitol and HAES–LX 5% occurred on days 7–14 of the experiment and lasted until its completion. Conclusions. The scheme of pharmacological correction of thermal damage to the thyroid gland with the introduction of hyperosmolar colloidal solutions with a multionic composition of lactoprotein with sorbitol and HAES–LX 5% is pathogenetically justified, can not only restore the functional activity of nephrocytes, but also prevent their damage in the dynamics of the postburn process.