Abstract:
Purpose: Preeclampsia (PE) is a specific syndrome of multiple organ insufficiency in case of pregnancy, which is
included in the panel of major obstetric syndromes and is among the main causes of maternal morbidity and
mortality in the whole world.
Material and methods: We conducted a prospective cohort study of 91 pregnant women to evaluate the
effectiveness of integrated use of maternal risk factors (2019 International Federation of Gynecology and
Obstetrics recommendations), placenta location (ultrasound at 18-20 weeks of gestation), and serum cystatin C
(at 18-36 weeks of gestation) in screening for pe in the second and third trimesters of gestation.
Results: In the subgroup of pregnant women with cystatin C levels greater than 1.0 mg/L (27 women), PE
developed in 26 women, which is 96.29% in percentage terms. When calculating GFR for cystatin C in a group with
PE there was a significant violation of the renal filtration system -52.46±2.08 (95% CI, 48.39-56.54), while in healthy
group the indicator is within normal limits -97.6±1.64 (95% CI, 94.38-100.82). In the analysis of the ratio of cystatin
C levels more than 1.0 mg / l and the development of PE, a sensitivity of 98.46%, specificity of 100% and accuracy
of 98.9%, p<0.001.
Conclusions: The data show that the combined model of maternal factors, ultrasound of the placenta and serum
cystatin C, is prognostically effective in pregnant women in the second and third trimesters of gestation and is a
reliable marker for the development of pe.
