Experimental background for hormone-vitamin complex using in course of rehabilitation after ionizing radiation

Abstract

The aim: To determine the efficacy of the original hormone-vitamin complex in terms of biochemical activity enhancement and muscle system functional activity restoration in the irradiated rat’s descendents. Materials and methods: The activity of NADP-dependent malatedehydrogenase and the content of ATP, ADP and AMP were determined in the blood, myocardium and thigh muscles of rats exposed to ionizing gamma-radiation. The rats were also checked in the forced swimming test. The efficacy of the hormone-vitamin complex was determined in all mentioned indexes. Results: Our results testify the expressed changes in muscle tissue functioning in an irradiated person, which was expressed by the dysfunction of biochemical reactions aimed at synthetic energy processes, and by the macroergic compounds level depletion together with physical performance minimization. Our data showed the hormone-vitamin complex injection to irradiated animals and their descendants improved the muscle energy resources due to glycolytic substrate phosphorylation enhancement and due to tricarboxylic acids cycle oxidative potential strengthening. Conclusions: Original scheme of post-radiation lesions complex pharmacological correction prevented the development of tissues providing with macroergic compounds, anaerobic processes strengthening, metabolic acidosis, weakening of both substrate phosphorylation and tricarboxylic acids cycle. The original scheme of ionizing radiation-induced energetic disorders pharmacological corrections in the irradiated animals’ descendents we consider as an experimental basis for the reasonability of these compound radioprotective effects testing during the physiotherapeutic treatment of persons exposed to ionizing radiation.