Development of qualitative methods of chemical analysis of octenidine hexafluorosilicate as a potential anti-caries agent

Abstract

The spread of dental caries is associated with the insufficient effectiveness of traditional means of prevention and the literacy of the population regarding proper oral hygiene. The search for new, more effective and safer fluoride means for the prevention and treatment of this disease and the development of methods for their qualitative chemical analysis is an urgent task of modern pharmacy. The previously synthesized octenidine hexafluorosilicate (OHFS) in an experiment on rats showed greater caries-preventive and periodontoprotective effectiveness than sodium fluoride as a reference drug. According to the determination of the toxicometric characteristics of OHFS in rats by the oral route of administration, this compound can be classified as a low-toxic substance of the IV toxicity class. The purpose of the work is to develop qualitative methods of chemical analysis of OHFS as a potential anti-caries agent.