Abstract:
The spread of dental caries is associated with the insufficient
effectiveness of traditional means of prevention and the literacy of the population
regarding proper oral hygiene. The search for new, more effective and safer fluoride
means for the prevention and treatment of this disease and the development of methods
for their qualitative chemical analysis is an urgent task of modern pharmacy. The
previously synthesized octenidine hexafluorosilicate (OHFS) in an experiment on rats
showed greater caries-preventive and periodontoprotective effectiveness than sodium
fluoride as a reference drug. According to the determination of the toxicometric
characteristics of OHFS in rats by the oral route of administration, this compound can
be classified as a low-toxic substance of the IV toxicity class.
The purpose of the work is to develop qualitative methods of chemical analysis
of OHFS as a potential anti-caries agent.
