Abstract:
The article deals with topical application of a new medication “Apior” gel in the complex therapy of radiation complications
in the oral cavity of patients with tumors of head and neck region undergoing radiation treatment. It was proved that the new
apigel subsides pronouncement of symptoms of xerostomia and oral radioreactions, arrests them, improves hygienic state of
oral cavity, salivation, positively affects nonspecific resistance of oral fluid, rendering a radioprotective action. A positive
effect of “Apior” gel is reached due to renewal of balance of pro- and antioxidant activity, reduction of level of
pro-inflammatory (i.e., IL-1and IL-6) and rise of anti-inflammatory (i.e., IL-4) cytokines level, restoration of secretory
immunoglobulin A, normalizes oral microbiocenosis.
