Abstract:
Transcranial magnetic stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold intensity to male
WAG/Rij rats. One group received stimuli, which involved motor responses of hindlimbs, rats of the second group received
sham stimulation. Electrocorticograms (ECoG) were recorded before and up to 2 hr from the moment of transcranial
magnetic stimulation. It was established that such stimulation engendered a reduction of spike-wave discharge (SWD) bursts
duration. This effect was most pronounced in 30 min from the moment of cessation of stimulation, when a decrease of
31.4% was noted in comparison with sham-stimulated control group. The number of bursts of spike-wave discharges was
reduced, but did not reach significant difference when compared both with pre-stimulative base-line level and with shamstimulated control rats. Bursts of spike-wave discharges restored up to pre-stimulative level in 90-150 minutes from the
moment of cessation of transcranial stimulation. It can be concluded that transcranical magnetic stimulation possessed an
ability to engender short-time suppression of bursts of spike-wave discharges in WAG/Rij rats.
