Therapeutic and prophylactic efficiency of polyfunctional anti-disbiotic drugs under conditions of experimental lipid intoxication

Abstract

Aim: to compare the therapeutic and prophylactic efficiency (TPE) of four polyfunctional antidisbiotic drugs (PFAD) in experimental lipid intoxication. Methods: TPE was assessed by the nature of changes in blood serum levels of biochemical markers of inflammation (elastase, MDA), bacteremia (urease), nonspecific immunity (lysozyme). The following PFAD were used: Kvertulin (quercetin + inulin + calcium citrate), Lekvin (lecithin + quercetin + inulin + calcium citrate), Lekasil (lecithin + milk thistle meal + calcium citrate) and Lysozyme-forte (lysozyme + quercetin + inulin + gelatin + calcium citrate). Lipid intoxication was carried out on rats by introducing thermal peroxide sunflower oil (TPSO) with food at a dose of 4 g/kg for 75 days. PFAD was administered from day 31 at a dose of 300 mg/kg for 45 days. Results: there was a significant increase in the level of elastase, MDA, urease and a significant decrease in the activity of lysozyme in the blood serum of rats treated with TPSO. After the introduction of all drugs, a significant decrease in the level of elastase, MDA, urease and a significant increase in the activity of lysozyme were observed. Conclusion: with lipid intoxication, a dysbiotic syndrome develops, manifested by bacteremia, a decrease in the level of nonspecific immunity and manifestations of systemic inflammation. Taking polyfunctional antidisbiotic drugs reduces bacteremia, enhances nonspecific immunity and prevents the development of systemic inflammation. The most effective remedy turned out to be "LysozymeForte".