Dynamics of vasoconstructor-vasodilation potential on the background of the development of experimental diabetic retinopathy

Abstract

Proved development of endothelial dysfunction in rats that was modeled experimental diabetic retinopathy, as evidenced by increased endothelin-1 levels. It was found that at each stage of the study, pathological vasoconstriction increases (p <0.001 compared with the intact group). It was revealed that simulated diabetic retinopathy negatively affects vasodilation potential, as evidenced by the analysis of the content of S-nitrosothiols in the blood of experimental animals (p <0.001 compared with the data of intact animals). In the analysis of vasoconstrictor-vasodilyatatsiynogo potential at each stage of the experiment proved the prevalence of pathological vasoconstriction (p <0.001). The weakening of the vasodilatory potential was step by step more gradual in comparison w ith the dynamics of the increase in the vasodilation potential. In a comparative experiment characteristic pathological stages most pronounced shifts mounted on stage III of diabetic retinopathy study simulated (180-day).