Dynamics of markers of endothelial dysfunction in experimental antiphospholipid syndrome

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dc.contributor.author Yakymenko, O. O. en
dc.contributor.author Savytskyi, V. I. en
dc.contributor.author Klochko, V. V. en
dc.contributor.author Savytskyi, I. V. en
dc.contributor.author Mykhailiuk, M. M. en
dc.contributor.author Gerasymenko, T. V. en
dc.contributor.author Badiuk, N. S. en
dc.date.accessioned 2021-06-18T06:53:55Z
dc.date.available 2021-06-18T06:53:55Z
dc.date.issued 2021
dc.identifier.citation Dynamics of markers of endothelial dysfunction in experimental antiphospholipid syndrome / О. О. Yakbmenko, V. I. Savytskyi, V. V. Klochko et al // pharmacologyonline. – 2021. – Vol. 1. – P. 74–81. en
dc.identifier.uri https://repo.odmu.edu.ua:443/xmlui/handle/123456789/9672
dc.description.abstract Analysis of the entire set of currently available factors allows us to consider antiphospholipid syndrome (APS) as a unique model of autoimmune platelet vasculopathy, the study of which is essential for determining the relationship between such fundamental pathological processes as atherosclerosis, vasculitis, blood clotting disorders and the immune system. At the same time, the diagnosis and treatment of APS is based on serological tests, and little attention is paid to hemostatic markers and endothelial dysfunction in this pathology. The aim of the study was to study the dynamics of endothelial state indicators in animals with simulated antiphospholipid syndrome and the effectiveness of their correction by introducing warfarin, immunoglobulin and L-arginine. Research results. Disruption of the functional state of the endothelium in animals with simulated antiphospholipid syndrome was found. A pronounced increase in the von Willebrand factor level (p <0.001) in the blood of rats with experimental APS was proved. It was revealed that the development of experimental antiphospholipid syndrome leads to an increase in the level of homocysteine in the blood of rats (p <0.001). The most pronounced results of correction were found in the fifth group, the animals of which received complex therapy with warfarin, immunoglobulin and L-arginine. en
dc.language.iso en en
dc.subject antiphospholipid syndrome en
dc.subject pathology en
dc.subject L-arginine en
dc.subject warfarin en
dc.subject immunoglobulin en
dc.subject endothelial dysfunction uk_UA
dc.title Dynamics of markers of endothelial dysfunction in experimental antiphospholipid syndrome en
dc.type Article en


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