Abstract:
Aim. It has been established that the consumption of thermoperoxide fats causes the
development of pathological processes in the tissues of the mouth, stomach, intestines and
liver. The purpose of this work is to determine the possibility of their normalization using oral
applications of phytogels.
Methods. Thermoperoxide oil (TPSO) was obtained by heating sunflower oil in the
presence of H2O2 at a temperature of +180 °C for 60 minutes. Oral TPSO applications were
made on the oral mucosa at a dose of 2.25 g/kg daily for 5 days. Used mucose-adhesive
phytogels "Kvertulin" (quercetin + inulin), "Biotrit" (juice from wheat sprout) and "Dubovy"
(extract of polyphenolic compounds from oak wood) in the form of oral applications at a dose
of 2.25 g/kg for half an hour before TPSO applications daily for 5 days. Elastase and urease activity and malonic dialdehyde (MDA) content were determined in homogenates of the
mucous membranes of the cheek, stomach, small and large intestines, as well as in the liver.
Results. Oral applications of TPSO increased the levels of MDA, elastase and urease
in the tissues of the digestive system. Applications of phytogels significantly normalized these
parameters.
Conclusions. Oral applications of TPSO cause the development of inflammation in the
digestive system, especially in the liver. Oral applications of phytogels have a protective
effect, especially "Kvertulin".
