Видання англійською мовою. Кафедра пропедевтики внутрішніх хвороб та терапії: Recent submissions

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The metabolic syndrome in the setting of general medicine

Yakimenko, O. O.; Oliynyk, D. A.; Oliynyk, A. A. (2024)

The study was carried out with the data-mining tool of the Medico2000 software on the medical records of 83 patients, aged between 52 and 69 years, divided into 44 males and 39 females, examined at the GP’s office. Among ...
Evaluation of treatment efficacy in patients with non-alcoholic steatohepatitis and heterozygotic familial hypercholesterolemia

Yakimenko, O.; Maznichenko, I.; Якименко, Е. А.; Мазниченко, Е. А. (2019)

The aim of the study was to increase the efficacy of treatment of patients with HFHC and NASH by developing a personified approach to the therapy with rosuvastatin 20 mg/day and combined hepatoprotector at the inpatient ...
Pharmacoeconomics as a tool to enhance efficency of health care services

Zakritov, D. O. (2018)

Today's cost-sensitive healthcare environment has created a competitive and challenging workplace for clinicians. Competition for diminishing resources has necessitated that the appraisal of healthcare goods and services ...
Additional opportunities for antihypertensive therapy improvement in young patients with arterial hypertension and concomitant obesity

Chernyshova, K.; Yakimenko, O.; Bondar, V.; Chernyshova, H.; Kolomiets, S.; Oliynyk, D.; Tbileli, V.; Maznichenko, I. E. (2022)

The high prevalence of arterial hypertension (AH) and concomitant obesity in young patients is not only a medical but also a social problem. It is important to develop additional modern approaches to the management of young ...
Changes in vasoconstructor-vasodilation potential of vessels in experimental antiphospholipid syndrome

Yakymenko, O. O.; Savytskyi, V. I.; Klochko, V. V.; Savytskyi, I. V.; Badiuk, N. S. (2021)

As a result of our study, the development of endothelial dysfunction in experimental antiphospholipid syndrome is confirmed: an increase in the marker of ED (endothelin-1) and a pathological increase in vasoconstrictor ...
Comprehensive treatment of osteoarthritis peformans with concomitant metabolic syndrome

Bohdan, N. М. (2016)

Osteoarthritis peformans is the most common pathology of the musculoskeletal system. OAP, combined with metabolic syndrome (MS), leads to an overuse of the knee joints operation, and is one of the main causes of premature ...
Genetic and biochemical markers of endothelial dysfunction in young patients with arterial hypertension and concomitant obesity

Yakimenko, O. O.; Chernyshova, K. S.; Bondar, V. M.; Tiron, O. I.; Maznichenko, Ie. A.; Якименко, О. О.; Чернишова, К. С.; Бондар, В. М.; Тірон, О. І.; Мазніченко, Є. О. (2021)

The total of 123 young hypertensive patients were examined with normal weight, overweight and obesity (average age 32.83±0.58 years old). They were performed genetic analysis of endothelial NO-synthase gene polymorphisms ...
Aldosterone synthase gene C-344Т polymorphism as a risk factor of early left ventricular remodeling in young hypertensive patients with obesity

Yakimenko, O.; Chernyshova, K.; Bondar, V.; Klochko, V.; Kolomiets, S.; Tbilieli, V.; Якименко, Е. А.; Чернышова, Е. С.; Бондарь, В. Н.; Клочко, В. В.; Коломиец, С. Н.; Тбилели, В. В. (2021)

The purposes of the research were to study the prevalence of C-344T polymorphism and the distribution of aldosterone synthase gene (CYP11B2) genotypes, to analyze the association of aldosterone concentration with aldosterone ...
Analysis of the efficacy of a comprehensive use of a hepatoprotector and statin in the treatment of experimental hypercholesterolemia with nonalcoholic fatty liver disease in rats (experimental study)

Yakimenko, O.; Kholodkova, О.; Maznichenko, Ie. (2018)

Nonalcoholic fatty liver disease (NAFLD) is a pandemic disease spread in the whole world and is found among the population of different age groups. Nonalcoholic steatohepatitis (NASH) is a progressing condition of NAFLD ...
Prospects for the use of integrated assessment of gene-candidates polymorphisms in the management of arterial hypertension: let’s start

Bondar, V.; Chernyshova, K.; Kolomiets, S.; Klochko, V.; Vasilets, V.; Halynska, V.; Oliynyk, D. (2019)

Nowadays a large amount of data about the frequency of gene-candidates polymorphisms occurrence in patients with arterial hypertension (AH) have been accumulated. The using of single polymorphisms for diagnostic and ...
Excessive accumulation of candidate gene polymorphisms in young hypertensive patients as a factor of increasing incidence of arterial hypertension at a young age

Bondar, V.; Yakimenko, O.; Chernyshova, K.; Klochko, V. (2021)

The concept of accumulation of candidate genes (CG) polymorphisms in the realization of the hypertensive phenotype is perspective both in understanding about the arterial hypertension (AH) formation as a disease with a ...
Dynamics of Il-6 and CK-18 concentration in blood plasma in patients with familial hypercholesterinemia with non-alcoholic steatohepatitis against the background of statin therapy and hepatoprotector

Maznichenko, Ie. A.; Мазниченко, Е. А. (2019)

There was made a comprehensive examination of 71 patients with FHC and NASH and formed groups of patients: I - n = 35 with FHC and NASH receiving rosuvastatin 20 mg / day; II - n = 36 of FHC and NASH who received rosuvastatin ...
Dynamics of markers of endothelial dysfunction in experimental antiphospholipid syndrome

Yakymenko, O. O.; Savytskyi, V. I.; Klochko, V. V.; Savytskyi, I. V.; Mykhailiuk, M. M.; Gerasymenko, T. V.; Badiuk, N. S. (2021)

Analysis of the entire set of currently available factors allows us to consider antiphospholipid syndrome (APS) as a unique model of autoimmune platelet vasculopathy, the study of which is essential for determining the ...
Integrative assessment of candidate gene polymorphisms distribution by forming a gene modification index in arterial hypertension with and without obesity: a new perspective in cardiology management

Bondar, V.; Chernyshova, K.; Chernyshova, H.; Kolomiiets, S.; Klochko, V.; Tbileli, V.; Kryzhanovska, O.; Dehtyar, Y. E.; Krasiluk, N.; Yershova, R.; Bondar, K. (2020)

The concept of evolutionary accumulation of candidate gene polymorphisms in the realization of the hypertensive phenotype becomes promising in understanding of arterial hypertension (AH). A large amount of data about genetic ...
Rituximab efficacy in caps

Yakymenko, O.; Vasylets, V.; Klochko, V.; Savytskyi, V.; Tikhonchuk, N. (2020)

Catastrophic antiphospholipid syndrome (CAPS) – thrombotic microvasculopathy, characterized by involvement of systems and organs with formation of their insufficiency. Therapy of glucocorticoids and immunosuppressants ...
Factors affecting the formation of public health in Ukraine (literature review)

Yakimenko, E. A.; Panov, B. V.; Mikhaylenko, V. L.; Gavrilenko, M. U. (2018)

The health of the population is one of the greatest values of mankind and a necessary condition for the social and economic development of each country. To realize the potential of each person throughout life, it is necessary ...
New models for assessing the impact of interactions of risk factors on the development of a fatal outcome of cardiovascular disease

Yakimenko, O.; Oliynyk, D.; Oliynyk, A.; Bondar, V.; Tbileli, V.; Chernyshova, K.; Palombo, C. (2020)

Various methods for determining cardiovascular risk does not allow to quantify the effect of direct impact of each risk factor and their interactions. In the current study, mathematical models have been used on the basis ...
Evaluation of treatment efficacy in patients with non-alcoholic-steatohepatitis and heterozygotic familial hypercholesterolemia

Yakimenko, О.; Maznichenko, I.; Якименко, Е. А.; Мазниченко, Е. А. (2019)

The aim of the study was to increase the efcacy of treatment of patients with HFHC and NASH by developing a personifed approach to the therapy with rosuvastatin 20 mg/day and combined hepatoprotector at the inpatient and ...
Effect of the drug from soybean and avocado on the course of osteoarthrosis of the knee joints with concomitant metabolic syndrome in women in the menopausal period

Yakimenko, O.; Bogdan, N. (2017)

Te most common articular pathology is osteoarthrosis of the knee joints. More than 10 % of the world's population suﬀers from this disease. Te development of osteoarthrosis (OA) is also aﬀected by metabolic syndrome (MS), ...
Correlation between genetic stratification of cardiovascular risk and traditional scale SCORE in patients with arterial hypertension

Bondar, V.; Chernyshova, K.; Kolomiets, S.; Kryzhanovskay, H.; Dehtyar, E. (2018)

Prognosis of cardiovascular risk (CVR) in patients with arterial hypertension (AH) is an important component of long-term management. The accumulated data of polymorphisms of candidate genes in AH form a reasonable prospect ...

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