Инъекции в десну растворов микробных токсинов (липополисахарида, гиалуронидазы или трипсина) вызывают развитие воспаления в периодонтите.
Aim: To determine the influence of microbial toxins on the development of inflammation in periodonte. Materials and methods: Microbial toxins: lipopolysaccharide (LPS) – 1 mg/ml, bacterial hyaluronidase (2 mg/ml) and trypsin (5 mg/ml) were introduced into rat gum at region of molar roots in doses 0,2 ml. After 3 hours the levels of inflammation markers (elastase, acide phosphatase, MDA) were determined in pulp, gum and serum. Results: The levels of inflammation markers raised into all tissues, but serum elastase only after the introduction of hyaluronidase and trypsin. The largest growth of inflammation markers was in pulp and gumafter introduction of hyaluronidase. Conclusion: The microbial toxins stimulate the inflammation into periodonte. The introduction of hyaluronidase in gum may by the experimental model of periodontite.
Ін’єкції в ясна розчинів мікробних токсинів (ліпополісахариду, гіалуронідази або трипсину) викликають розвиток запалення в періодонті.
