Сравнительная оценка лечебно-профилактического действия оральных мукозопротекторов "Капосол" и "Кверцетин"

Abstract

На модели эндотоксинового стоматита показано мукозопротекторное действии зубного эликсира "Квертулин", содержащего кверцетин, инулин и цитрат кальция, которое связано с его способностью снижать степень дисбиоза. Препарат "Капосол" оказался неэффективным.

На моделі ендотоксинового стоматиту показана мукозопротекторна дія зубного еліксиру "Квертулін", що містить кверцетин, інулин і цитрат кальцію, яка залежить від його здатності знижувати ступінь дисбіозу. Препарат "Капосол" виявився неефективним.

Mucosa protectant agents have a protective antiinflammatory effect on mucous membranes, including the oral mucosa, two of them are "Caphosol" and "Kvertulin." Our purpose was to compare the therapeutic efficacy of mouthwashes "Caphosol" and "Kvertulin" for intestinal endotoxininduced stomatitis in rats. Materials and methods: Experiment was carried out on 49 Wistar rats, which were divided into 4 groups: 1 - standard, 2 - "stomatitis", 3 - "stomatitis" + "Caphosol", 4 - "stomatitis" + "Kvertulin." Resalts: The study demonstrated that the level of inflammatory markers (MDA and elastase) significantly increased. "Caphosol" and "Kvertulin" did not significantly affect on these parameters. We could only note a tendency to reduce the activity of elastase. During stomatitis we noted the increase of urease activity. "Caphosol" did not affect on that index, whereas "Kvertulin" significantly reduced the urease activity. The activity of lysozyme decreased during stomatitis. "Caphosol" had a little affect on the level of that index, whereas "Kvertulin" significantly increased the activity of lysozyme. The degree of dysbiosis in the oral mucosa was almost three-times increased during stomatitis. "Caphosol" did not significantly reduce that index, while "Kvertulin" significantly (almost 2-times) reduced the degree of dysbiosis. The activity of catalase reduced and prooxidant-antioxidant index significantly reduced during stomatitis. "Caphosol" and "Kvertulin" increased the activity of catalase and do not affect on the prooxidant-antioxidant index. Conclusion: ‘’Kvertulin’’ demonstrated significantly mucosprotective activity.