On the mechanism of antiseizure effect engendered with nucleus dentatus stimulation

Abstract

Via sodium salt penicillin solution (10.000 IU/ml) application upon posterior right sygmoid gyrus epileptic foci have been created in anaesthetized, myorelaxed and artificially ventilated cats. Electrical stimulations (ES) (0,5 ms, 100-180 mcA duration of trial 3,0-5,0 s) of the left n.dentatus (H = 9,5; L = 8,0: P = -9,0) have been performed. The early stage of penicillin foci development (first 4,0–7,5 min) was characterized by the absence of first positive potential (FPP). The precipitation of pronounced FPP along with the diminishing of negative component of spike registered in 5–20 s from the moment of ES (100 Hz) cessation delivered in 1,0–2,0 min from the moment of epileptic discharges appearance. In 4 out from 7 cases the complete “reversion” of discharges from negative to positive one has been observed.