Abstract:
Placental dysfunction (PD) is one of the reasons that determine the rates of perinatal morbidity
and mortality. Recent studies have demonstrated a certain effect of vitamin D (VD) on PD development.
Objective. To determine the possible relationship between VD status and faulty placentation and its
structural features in PD pregnant women. Materials and methods. 56 pregnant women with PD and
40 healthy women with a physiological course of pregnancy were examined. The level of VD in the
patients’ blood was determined by enzyme-linked immunoassay (EIA) method; placenta’s attitude and
its structural and functional features were determined by ultrasound, Dopplerometric methods. Results.
66.07% of PD pregnant women under examination had placenta’s abnormal/faulty attitude or its
structural changes. Normal placenta’s attitude without structural organometric changes was noted only
in 33.93% of PD pregnant women (OR=192,18 95%; CI 25.68 – 1438.38; χ2 = 98.51; p<0,001). 35.13% of
pregnant women with abnormal placentation had calcitriol level corresponding to suboptimal (20-30
ng / ml) or deficient status with VD significantly lower average blood level compared to the control
group (31.40 ± 8.6 VS 43.54 ng / ml; p ≤ 0.05). Conclusions. Calcitriol may have some influence on the
formation, development and functioning of utero-placental-fetal blood circulation. Further researches
to obtain information on the role of VD in this process are needed.
