The pleiotropic effects of vitamin D (VD), whose active form is synthesized in the kidneys, play a certain role
both in forming and functioning the feto-placental system, including various pregnancy complications.
The aim of the study was to evaluate the vitamin D status in pregnant women with placental dysfunction (PD) and chronic
inflammatory kidney disease (CIKD).
During 24–34 pregnancy weeks, 56 pregnant women with PD were examined (main group ‒ I); 24 patients (42.85 %)
had chronic pyelonephritis (group IA). The control group (group II) had 31 conditionally healthy pregnant women. The total
VD level in the blood was determined by ELISA; in addition to the general clinical standard examination, the urine also
underwent bacteriological examination.
The VD mean level in pregnant women with PD and CIKD was significantly lower than that in the control group (31.08 ± 7.2
and 45.42 ± 9.67 ng/ml (p < 0.01)). Only 33.33 % of pregnant women in group IA had a VD optimum, as well as 93.55 %
(p < 0.01) in the control group and 17.86 % in group I. 8.33 % of pregnant women had a VD deficiency in group IA (RR = 2.09;
CI 95 % ‒ 1.8‒2.42). The patients with a VD-deficiency were absent in the control group. 58.33 % of women in group ІА had
a suboptimal VD level and 6.45% in the control group (RR = 3.57; CI 95 % ‒ 1.62‒7.88). Bacteriuria was observed in all pregnant
women with a VD-deficient or suboptimal level. At the optimum VD level, bacteriuria was diagnosed twice less (χ2 = 66.67;
p < 0.01). In patients with an inadequate VD level, CIKD was diagnosed 3.8 times more (RR = 3.57; CI 95 % ‒ 1.62‒7.88). The pleiotropic effects of vitamin D (VD), whose active form is synthesized in the kidneys, play a certain role
both in forming and functioning the feto-placental system, including various pregnancy complications.
The aim of the study was to evaluate the vitamin D status in pregnant women with placental dysfunction (PD) and chronic
inflammatory kidney disease (CIKD).
During 24–34 pregnancy weeks, 56 pregnant women with PD were examined (main group ‒ I); 24 patients (42.85 %)
had chronic pyelonephritis (group IA). The control group (group II) had 31 conditionally healthy pregnant women. The total
VD level in the blood was determined by ELISA; in addition to the general clinical standard examination, the urine also
underwent bacteriological examination.
The VD mean level in pregnant women with PD and CIKD was significantly lower than that in the control group (31.08 ± 7.2
and 45.42 ± 9.67 ng/ml (p < 0.01)). Only 33.33 % of pregnant women in group IA had a VD optimum, as well as 93.55 %
(p < 0.01) in the control group and 17.86 % in group I. 8.33 % of pregnant women had a VD deficiency in group IA (RR = 2.09;
CI 95 % ‒ 1.8‒2.42). The patients with a VD-deficiency were absent in the control group. 58.33 % of women in group ІА had
a suboptimal VD level and 6.45% in the control group (RR = 3.57; CI 95 % ‒ 1.62‒7.88). Bacteriuria was observed in all pregnant
women with a VD-deficient or suboptimal level. At the optimum VD level, bacteriuria was diagnosed twice less (χ2 = 66.67;
p < 0.01). In patients with an inadequate VD level, CIKD was diagnosed 3.8 times more (RR = 3.57; CI 95 % ‒ 1.62‒7.88). The pleiotropic effects of vitamin D (VD), whose active form is synthesized in the kidneys, play a certain role
both in forming and functioning the feto-placental system, including various pregnancy complications.
The aim of the study was to evaluate the vitamin D status in pregnant women with placental dysfunction (PD) and chronic
inflammatory kidney disease (CIKD).
During 24–34 pregnancy weeks, 56 pregnant women with PD were examined (main group ‒ I); 24 patients (42.85 %)
had chronic pyelonephritis (group IA). The control group (group II) had 31 conditionally healthy pregnant women. The total
VD level in the blood was determined by ELISA; in addition to the general clinical standard examination, the urine also
underwent bacteriological examination.
The VD mean level in pregnant women with PD and CIKD was significantly lower than that in the control group (31.08 ± 7.2
and 45.42 ± 9.67 ng/ml (p < 0.01)). Only 33.33 % of pregnant women in group IA had a VD optimum, as well as 93.55 %
(p < 0.01) in the control group and 17.86 % in group I. 8.33 % of pregnant women had a VD deficiency in group IA (RR = 2.09;
CI 95 % ‒ 1.8‒2.42). The patients with a VD-deficiency were absent in the control group. 58.33 % of women in group ІА had
a suboptimal VD level and 6.45% in the control group (RR = 3.57; CI 95 % ‒ 1.62‒7.88). Bacteriuria was observed in all pregnant
women with a VD-deficient or suboptimal level. At the optimum VD level, bacteriuria was diagnosed twice less (χ2 = 66.67;
p < 0.01). In patients with an inadequate VD level, CIKD was diagnosed 3.8 times more (RR = 3.57; CI 95 % ‒ 1.62‒7.88). The pleiotropic effects of vitamin D (VD), whose active form is synthesized in the kidneys, play a certain role
both in forming and functioning the feto-placental system, including various pregnancy complications.
The aim of the study was to evaluate the vitamin D status in pregnant women with placental dysfunction (PD) and chronic
inflammatory kidney disease (CIKD).
During 24–34 pregnancy weeks, 56 pregnant women with PD were examined (main group ‒ I); 24 patients (42.85 %)
had chronic pyelonephritis (group IA). The control group (group II) had 31 conditionally healthy pregnant women. The total
VD level in the blood was determined by ELISA; in addition to the general clinical standard examination, the urine also
underwent bacteriological examination.
The VD mean level in pregnant women with PD and CIKD was significantly lower than that in the control group (31.08 ± 7.2
and 45.42 ± 9.67 ng/ml (p < 0.01)). Only 33.33 % of pregnant women in group IA had a VD optimum, as well as 93.55 %
(p < 0.01) in the control group and 17.86 % in group I. 8.33 % of pregnant women had a VD deficiency in group IA (RR = 2.09;
CI 95 % ‒ 1.8‒2.42). The patients with a VD-deficiency were absent in the control group. 58.33 % of women in group ІА had
a suboptimal VD level and 6.45% in the control group (RR = 3.57; CI 95 % ‒ 1.62‒7.88). Bacteriuria was observed in all pregnant
women with a VD-deficient or suboptimal level. At the optimum VD level, bacteriuria was diagnosed twice less (χ2 = 66.67;
p < 0.01). In patients with an inadequate VD level, CIKD was diagnosed 3.8 times more (RR = 3.57; CI 95 % ‒ 1.62‒7.88). A significantly calcitriol reduction in pregnant women with placental dysfunction suggests that the deficiency or the suboptimal
level of vitamin D and inflammatory kidney diseases may be the interdependent processes that play a decisive role in the formation
of placental dysfunction.
Плейотропные эффекты витамина D (VD), активная форма которого синтезируется в почках, играют
определенную роль в формировании и функционировании фетоплацентарной системы, в том числе при различных
осложнениях беременности.
Цель работы ‒ оценка уровня витамина D у беременных с плацентарной дисфункцией (ПД) и хроническими
воспалительными заболеваниями почек (ХВЗП).
В течение 24‒34 недель беременности обследовано 56 женщин с ПД (группа I ‒ основная), 24 (42,85 %) из которых страдали хроническим пиелонефритом (группа IA). Контрольную группу (группа II) составила 31 условно
здоровая беременная женщина. Уровень общего VD в крови определяли методом ИФА; в дополнение к общему стандартному клиническому исследованию было выполнено также бактериологическое исследование мочи.
Установлено, что средний уровень VD у беременных с ПД и хронической болезнью почек был значительно
ниже, чем в контрольной группе (31,08 ± 7,2 и 45,42 ± 9,67 нг/мл (р < 0,01)). Оптимум VD выявлен только у 33,33 % беременных женщин в группе IA, в контрольной группе – у 93,55 % (р < 0,01), у 17,86 % обследованных в группе I
и у 8,33 % беременных в группе IA был дефицит VD (ОR = 2,09; ДИ 95 % ‒ 1,8‒2,42). Женщин с VD-дефицитным
статусом в контрольной группе не было. У 58,33 % женщин в группе ІА был субоптимальный уровень VD, в контрольной
группе ‒ у 6,45 % (ОR = 3,57; ДИ 95 % ‒ 1,62‒7,88). Бактериурия диагностирована у всех беременных
с VD-дефицитным или субоптимальным уровнем. При оптимальном уровне VD бактериурия определялась в 2 раза
реже (χ2 = 66,67; р < 0,01). У пациентов с неадекватным уровнем VD ХВЗП диагностировали в 3,8 раза чаще (ОR = 3,57;
ДИ 95 % ‒ 1,62‒7,88).
Значительное снижение уровня кальцитриола у беременных с дисфункцией плаценты позволяет предположить,
что дефицит или недостаточный уровень VD и воспалительные заболевания почек являются взаимозависимыми
процессами, которые играют важную роль в формировании плацентарной дисфункции.
