Abstract:
Background: The World Health Organization describes the metabolic syndrome (MS) as a "21st
Century Pandemic." The pathogenesis of MS is complex and completely not studied, which justifies the
importance of conducting research in this field, including experimental ones. Recently, in order to treat
MS and its complications, along with drug therapy, non-pharmacological agents are used - natural
therapeutic resources, which include mineral water (MW). MW are widely used in medical practice,
due to the possibility of prolonged use, the combination of general non-specific effects on the processes
of body sanogenesis in general and local pathogenetic mechanisms.
Objective: To investigate the effect of MW with increased content of organic substances on its internal
application to the metabolic rate of experimental animals with the MS.
Materials and Methods: In the experiment, 40 white male rats weighing 230.0 – 250.0 g were used.
For reproduction of the MS model, the animals were kept for 60 days in a standard diet, while the rats
additionally received 30 grams of white bread crumbs per animal and consumed only 10% fructose
solution in distilled water (as a drinking liquid). MW was injected into the esophagus of animals with a
soft probe with olive, once a day for 12 consecutive days, at a dose of 1% of the body weight of the
animal.
Results: At day 60 of the experiment in rats with MS, blood glucose levels were increased by 3 mmol/l
(p < 0,01), cholesterol and triglycerides by 32 and 154% (p < 0.01). Weight of animals increased by
14% (p < 0,01), and the use of a solution of fructose by 100%. Under the influence of MW, the weight
of animals decreased by 8% (p < 0.01), the use of a solution of fructose by 50% (р < 0,01). The level of
glucose decreased by 2 mmol/l, the cholesterol content was completely restored (p > 0,5), and the
content of triglycerides remained elevated (p < 0,001).
Conclusion: MS is a serious and long-lasting pathology, its development causes serious rearrangements
in the body. Established corrective effect of MW with increased content of organic substances on
separate parts of pathogenesis of MS, although not carried out in full, but is of a stable nature.
