Abstract:
Thanks to the use of nuclear energy a society lives under the conditions of increased radiation background.
Malformations and other inherited diseases caused by damage to the genetic apparatus by low doses of irradiation
appear even in the remote generations. It determines the need for research of the remote effects of irradiation of
parents on their posterity. One of the most radiosensitive tissues is small intestine which is responsible for the last
stages of digestion and absorption of nutrients. Therefore the aim of our work was the analysis of the role of satiety
of the parents during irradiation in the assimilation of substrates of the protein origin in two generations of their
posterity.
Materials and methods: In vitro were studied parameters of transport of free glycine and “peptide” glycine
formed from glycyl-glycine in the small intestine of the 2nd generation of posterity of male rats, that were irradiated
by a dose 0,5 Gy after taking meal, and intact females.
Results: Parameters of the transport of the free glycine and “peptide” glycine in the small intestine of the 2nd
generation of posterity of irradiated satiety male rats are lower than corresponding parameters in the 1st generation
and in the intact groups but are in the borders of active component of transport. Stability of transport of the free
glycine and “peptide” glycine are higher than in the corresponding intact groups.
Conclusions: In comparison with the corresponding data for 2nd generation of irradiated fasting male rats,
satiety of the male-predecessors lead to the stabilization of the activity of transport system as for free glycine, so for
the “peptide” glycine both in the small intestine of their posterity. Apparently, the protective effect of the presence of
food in the gastrointestinal tract of precursor at exposure is realized by stabilizing of the activity of transport system
for free glycine and "peptide" glycine both in the small intestine of two generations of posterity, and maintaining its
work at the level necessary and sufficient for normal body functioning.
