Abstract:
Non-alcoholic fat liver disease (NAFLD) is an urgent problem of modern healthcare and ranks first among all liver diseases
worldwide, assuming the nature of an epidemic. The pathogenesis of NAFLD is complex and insufficiently studied, and therefore
pharmacological therapy is not always effective and causes negative side effects (or complications). Treatment with mineral waters
(MW) is one of the most effective methods of treating diseases of the digestive system and metabolic disorders. Objective: to study
the effect of sulphate MW on metabolic disturbances in rats with the experimental NAFLD model for the purpose of scientifically
substantiating its use in the complex of treatment of patients. Morphological studies have established that the use of sulfate MW in
healthy animals causes an increase in the functional activity of the liver and stomach, which indicates a pronounced biologic activity
of this MW. In animals under the influence of sulphate MW was determined a significant reduction in hepatic steatosis according
to the morphological study of biopsy specimens, restoration of the processes of bile formation and bile secretion, positive dynamics
in the restoration of energy-dependent transmembrane ion transport. Clinical studies in the complex treatment of NAFLD with the
use of sulphate MW established normalization of lipid metabolism, improvement of the functional state of the liver, decreased
insulin resistance, recovery of adiponectin secretion.
