Investigation of the effect of natural chloride-magnesium solution on the functional state of kidneys with experimental arthrosis

Abstract

Arthrosis was simulated by means of dexamethasone injection into the knee joint of albino Wistar outbred rats. Urine secreting and excretory function of the kidneys against the ground of development of pathological process was examined in rats of the 1st group, in the 2nd group it was studied against underlying arthrosis and transdermal use of balneological remedy “Magnesium oil” (containing 95% of Magnesium chloride). Healthy rats constituted the 3rd control group. Diurnal urine exertion was found to be 17% less as much in rats with arthrosis at the expense of 43% decrease of glomerular filtration rate, 30% decrease of potassium, sodium and chlorine excretion and 10% decrease of creatinine excretion. Transdermal application of chloride-magnesium solution with general mineralization of 15 g/L resulted in practically complete restoration of urine secreting kidney function with a partial restoration of their excretory function – excretion of potassium and creatinine did not differ from the level of that of the 3rd group, and secretion of sodium and chlorine increased as compared to the 1st group but did not reach the level of that of control. Analysis of the data obtained enables to suggest that functional kidney state is disturbed in case of arthrosis development. Even partial restoration of the kidney function under the influence of magnesium-containing remedy results in stabilization of homeostasis and promotes elimination of degenerative changes in joints.