В даному дослідженні розглянута проблема покращення ефективності фармакотерапії шляхов вивчення сироваткових та плазмових гомеостатичних зсувів на фоні різних комбінацій препаратів у пацієнтів літнього віку з первинною артеріальною гіпертензією II стадії та ішемічною хворобою серця. За допомогою методу ЛКС-метрії виявлені та охарактеризовані особливості спектральної картини при застосуванні трьох комбінацій препаратів у пацієнтів з вищезазначеною паталогією.
In this investigation problem of pharmacotherapy efficacy improvement was observed by mean of studying plasma and serum homeostatic alterations under the influence of different combinations in elderly with primary hypertension II stage combined with ischemic heart disease. For this aim 60 elder patients were examined and treated in the University Clinic of Odessa National Medical University. Mean age of the patients was 67.2±3.8 years. Depending on prescribed treatment regimen (TR) all the patients were divided into 3 groups: lisinopril, cardiomagnil – TR I; lisinopril, bisoprolol, cardiomagnil – TR II; lisinopril, bisoprolol, indapamide, cardiomagnil – TR III. N=20 in all the groups. Laser correlation spectrometry (LCS) was special biophysical investigation method. Blood serum and plasma were investigated biomaterial. TR I led to increase of intoxication processes in both investigated liquids – serum and plasma. TR II was effective in decrease of catabolic reactions and increase of anabolic ones in plasma, but in serum it caused decrease of anabolic alterations. TR III improved serum homeostasis condition, while in plasma anabolic reactions increased but in the same time was revealed growth of intoxication processes. LCS is rather sensitive method in reflection of blood serum and plasma homeostatic condition as before the treatment as after it. It allows reveal features of spectral picture after usage of specific combination. For further confirmation of informative capacity of the method must be found out associations of the LCS results with other laboratory investigations.
