Abstract:
The aim of the study was to develop a personified method of endometrium preparation
for the transfer of vitrified / warmed embryos in women with the development of OHSS in
IVF programs. 39 women with early OHSS after IVF, who were undergoing personalized
correction of the morphofunctional state of the endometrium, and 39 patients with baseline
OHSS II group undergoing standard therapy were examined and treated. Control group
consisted of women without OHSS in the IVF cycle. Personalized correction of the
morphofunctional state of the endometrium includes traditional hormonal replacement
therapy and addition of adjuvants: preparation with extract of horse chestnut and thiamine
hydrochloride, vitamin E, serratiopeptidase, myo-inositol, the product of proteolysis of the
placenta of cattle, L-arginine aspartate. The application of the developed method for the
preparation of endometrium for the transfer of vitrified / warmed embryos by the developed
method contributed to the prolongation of pregnancy and the increase in the number of live
births in 2,11 times (OR 3.17; 95% CI 1.20-8.39; p<0,02). The increase in absolute benefit
(therapeutic benefit) of the proposed person-adjusted correction is 25.64% (95% CI 5.12-
46.16%), an increase in relative benefit corresponds to a clinically significant effect of
111.10% (95% CI 9.40 – 307.40 %), the number of patients to be treated is 3.90 (95% CI 2.17-19.52). The developed method is effective for the preparation of endometrium for the
transfer of vitrified / warmed embryos.
