Abstract:
Background: Traumatic brain injury is one of the most serious problems of modern
medicine that plays the dominant role in the morbidity and mortality of population of the
economically developed countries. This article presents the findings of the experimental
study of the effect of a mild traumatic brain injury (TBI) on the morphology of rats’ kidney.
Material and methods: The experiment was performed on 70 adult white rats 3 months of
age. The mild TBI was modeled by the Impact-Acceleration Model - free fall of weight in
the parieto-occipital area. For histopathological comparison, the samples were taken on the
1st, 3rd, 5th, 7th, 14th, 21st days after TBI. Results: Examination of the rat’s kidney histological slides on the 1st, 3rd, 5th, 7th, 14th,
and 21st days after the traumatic brain injury showed manifested changes in the
bloodstream and structural changes in the kidney parenchyma, particularly, dilatation of the
capillaries and veins in the initial period. It also showed perivascular lymphocytic
infiltration, dystrophic and necrotic processes in the form of the focal destruction of the
renal tubule, and renal corpuscles with diapedesis and perivascular hemorrhages on the 5th
and 7th days after the TBI. There were also the focal signs of perivascular and glomerular
sclerosis observed on the 14th and 21st days after the injury.
Conclusions: The greatest changes in the rats’ kidneys appear on the 5th – 7th days after
the injury, which have a clear tendency to decrease after that.
