Correlation analysis of GSTP1 gene polymorphism with morbidity of primary metastatic colorectal cancer

Abstract

Colorectal cancer (CRC) is one of the most common malignancies. Susceptibility to malignant processes is mediated by genetically driven differences in the effectiveness of detoxification of potential carcinogens. One of the factors that may influence the risk of CRC is the glutathione-S-transferase (GST) gene family that encodes glutathione transferase enzymes. The GSTP1 gene is expressed both in normal and pathological conditions. Determining its specific alleles may be a marker of CRC. The aim of the research – to study GSTP1 gene polymorphism, which is likely to be more common among patients with primary metastatic colorectal cancer compared with healthy population. Materials and methods. The study involved 12 patients with primary metastatic colorectal cancer aged 43 to 72 years, the control group was represented by a sample of 31 people without cancer. Results. The incidence of advanced CRC in the presence of GSPT1 Val/Val (aa) polymorphism is statistically significantly higher than in the presence of Ile/Ile (AA) and Ile/Val (Aa) GSPT1 polymorphism. Conclusions. Among people with GSTP1 Val/Val (aa) polymorphism, primary CRC is 4.4 times more likely than among people with GSPT1 Ile/Ile (AA) and Ile/Val (Aa) polymorphisms, which are statistically significant (p<0.05). The obtained results indicate the possibility of conducting a genetic study of GSTP1 polymorphism to form groups of potential risk of CRC.