Технологія низькочастотної п’єзотромбоеластографії у моніторингу протитромботичної терапії

Abstract

Метою роботи була демонстрація можливості моніторингу ПТ цільної крові для персоніфікованої оцінки ефективності засобів протитромботичної терапії.

The article presents information about new technology for whole blood haemostatic potential evaluation in haemocoagulation process — low-frequency piezotromboelastography, that allows to perform integrative evaluation of its characteristics. According to data, which was received for antiplatelet (COX-1 inhibitor — acetylsalicylic acid, platelets ADP-receptors blocker — clopidogrel) and anticoagulant (unfractionated heparin — heparinate, LMWH — enoxaparine) agents, affordances for perioperative and personalized evaluation of their pharmacodynamic were shown. New data about specific and pleiotropic effects of antitrombotic drugs was received. Specific response of haemostatic potential to intake of antiplatelet agents is decrease hemocytes aggregation activity, that representing as increase in blood suspense stability and decrease of contact coagulation intensity. Pleiotropic effect of antiplatelet treatment is represented as tendency of haemostatic potential shift to structural and chronometric hypocoagulation. As results of anticoagulant drugs pharmacodynamic evaluation, their maximal duration of action on haemostatic potential was revealed as well as the duration of anticoagulant effect. Specific response of haemostatic potential to intake of anticoagulant agents is a development of structural and chronometric hypocoagulation, which occur due to decrease of proteolytic stage of fibrinogenesis and inhibition processes of lateral assembly of fibrin activity.