Метою роботи була демонстрація можливості моніторингу ПТ цільної крові для персоніфікованої оцінки ефективності засобів протитромботичної терапії.
The article presents information about new technology for whole blood haemostatic
potential evaluation in haemocoagulation process — low-frequency piezotromboelastography,
that allows to perform integrative evaluation of its characteristics.
According to data, which was received for antiplatelet (COX-1 inhibitor —
acetylsalicylic acid, platelets ADP-receptors blocker — clopidogrel) and anticoagulant
(unfractionated heparin — heparinate, LMWH — enoxaparine) agents, affordances
for perioperative and personalized evaluation of their pharmacodynamic
were shown. New data about specific and pleiotropic effects of antitrombotic
drugs was received. Specific response of haemostatic potential to intake of antiplatelet
agents is decrease hemocytes aggregation activity, that representing as increase
in blood suspense stability and decrease of contact coagulation intensity. Pleiotropic
effect of antiplatelet treatment is represented as tendency of haemostatic potential
shift to structural and chronometric hypocoagulation. As results of anticoagulant
drugs pharmacodynamic evaluation, their maximal duration of action on haemostatic
potential was revealed as well as the duration of anticoagulant effect. Specific
response of haemostatic potential to intake of anticoagulant agents is a development
of structural and chronometric hypocoagulation, which occur due to decrease
of proteolytic stage of fibrinogenesis and inhibition processes of lateral assembly of
fibrin activity.
