Abstract:
In white rats in the setting of development of metabolic syndrome inhibition of
the urinary and excretory functions of the kidney, with impaired water-ion
balance (the kidneys excrete slightly hyperosmotic urine in a small amount) on
the background of structural signs of dystrophies. Daily diuresis is reduced by
37% due to a decrease in glomerular filtration rate (GFR) by 22% and an
increase in the percentage of tubular reabsorption (p <0.001), excretion of
creatinine, urea and chloride decreased by 22%, 15% and 56%. The excretion of potassium and sodium ions increases by 14% and 38%, respectively. The daily
urine is greatly delayed. Two-week internal course administration of lowmineralized sodium chloride water has a positive effect on impaired renal
function: the volume of diuresis is increased by 15% by accelerating GFR by
20% and restoring the value of tubular reabsorption. Creatinine excretion is
increased by 20% and urea by 32%. The excretion of potassium and sodium ions
is increased by 50% and 166%, respectively.
Excretion of chloride ions and urine pH is fully restored. Microscopically
determined residual manifestations of dystrophic processes in the kidneys,
which against the background of the recovery of processes of urination and
stimulation of ion-regulating and excretory functions of the kidneys, indicates
the ability of the applied sodium chloride MW to correct the structural and
functional disorders of the metabolic syndrome.
