Abstract:
The role of the calcitriol / vitamin D receptor (VD) endocrine system and the
pleiotropic effects of this system in the pathogenetic mechanisms of various diseases
development, in particular complications of pregnancy, has attracted researches’ increasing
attention in recent years.
The aim of the work: to compare the VD-status and frequency of occurrence of
polymorphism of the VDR gene (BsmI (A> G, rs1544410) in patients with a physiological
course of the gestation process and in patients with placental dysfunction (PD).
Materials and methods. 56 pregnant women with PD (the main group) and 40
patients with a physiological pregnancy (control group) were examined.
VD status was determined by ELISA at level 25 (OH) D in serum, the frequency of
BsmI polymorphism of the VDR gene (rs1544410) by polymerase chain reaction (PCR).
Results. The average index of VD (31.40 ± 8.6) ng / ml in patients with PD is
significantly lower than in patients with physiological pregnancy (43.54 ± 11.20) ng / ml,
(p ≤ 0.05 ).
In patients with PD, homozygous carrier for the A-allele was found in 12% of cases,
in healthy pregnant women - in 16.7%, (р ≥ 0.05), for the G-allele - in 20% and 47.20%, (р ≤ 0.01) cases, respectively to groups. Heterozygous combination of A / G alleles was noted
in 68% of patients with PD and in 36.10% of the control group patients. In pregnant women
with BsmI polymorphism of calcitriol gene (genotype A / G) PD was 3.7 times more frequent
(68% vs 36.10% : RR = 2.1, CI 1.0-6.6, OR = 3.7, CI 1.1-13.1).
Conclusions. Vitamin D insufficiency or deficiency can be one of the reasons of PD
formation. In carriers of BsmIgene’s polymorphism encoding VD receptor with genotype A /
G, the course of pregnancy is complicated by placental dysfunction 3.7 times more often than
in women without this polymorphism.
