• Analysis of the efficacy of a comprehensive use of a hepatoprotector and statin in the treatment of experimental hypercholesterolemia with nonalcoholic fatty liver disease in rats (experimental study) 

  Yakimenko, O.; Kholodkova, О.; Maznichenko, Ie. (2018)

  Nonalcoholic fatty liver disease (NAFLD) is a pandemic disease spread in the whole world and is found among the population of different age groups. Nonalcoholic steatohepatitis (NASH) is a progressing condition of NAFLD ...
• Cumulative cardiotoxic effect of bleomycin in experiment 

  Gozhenko, A.; Bestanchuk, O.; Kaschenko, O.; Narbutova, T. (2021)

  The aim of the study was to evaluate the cumulative toxic effect of bleomycin under experimental conditions Material and Methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. ...
• Cardiotoxic effect of bleomycin with a single administration in the experiment 

  Bestanchuk, E.; Gozhenko, A.; Kashchenko, O.; Narbutova, T.; Berezovskyi, O.; Zаkharova, V. (2021)

  The aim of the study was to evaluate the effect of a single injection of bleomycin on the heart Material and methods. The study was conducted in the Research Institute of Transport Medicine during 2016-2021. The experimental ...
• Clinical and morphological parallels in preterm birth 

  Sitnikova, V. O.; Nadvorna, O. M.; Rozhkovska, N. N.; Kashian, O. V. (2021)

  The aim of the study was to establish a link between the timing of preterm birth and clinical groups of women of different ages. There were demonstrated the differences in the incidence of preterm birth among women of ...
• Determination of safety profile of reparative activity of the new hygienic product “Apiprol” 

  Kravchenko, L.; Appelkhans, E.; Unhurian, L.; Shcherbakov, S.; Goncharenko, O.; Ivanova, Ya. (2021)

  The aim: To prove safety of the new elixir and determine the effect on regenerative processes under conditions of the experimental trauma. Materials and methods: The formula of the new dental elixir “Apiprol” includes ...
• Seroprevalence of babesiosis in immunocompetent and immunocompromised individuals 

  Bondarenko, A. V.; Torianyk, I. I.; Pokhil S., I.; Katsapov, D. V.; Lytvynenko, M. V.; Lantukh, I. V.; Bocharova, T. V.; Gargin, V. V. (2021)

  Interest in Babesia species is gaining an increasing attention as an emerging tick-borne pathogen. Infection is primarily transmitted through Ixodes ticks, and alternatively by blood transfusions from asymptomatic donors. The ...
• Anaplasmosis: experimental immunodeficient state mod 

  Bondarenko, A. V.; Pokhil, S. I.; Lytvynenko, M. V.; Bocharova, T. V.; Gargin, V. V. (2019)

  The recently described anaplasmosis infection is widespread but concerns to the insufficiently known group of diseases. The aim of our research is the development of uniform biological model for reproducing of artificial ...
• Morpho-functional changes in endometrium under the influence of chronic alcoholism 

  Lytvynenko, M.; Narbutova, T.; Vasylyev, V.; Bondarenko, A.; Gargin, V.; Литвиненко, М. В.; Нарбутова, Т. Е.; Васильев, В. В.; Бондаренко, А. В.; Гаргин, В. В. (2021)

  According to data that would have been obtained precisely as a result of studying the changes caused by alcohol abuse in the female body which can help solve many abnormal conditions developing in the female reproductive ...
• The features of endometrium structure in alcohol-abused HIV-infected individuals 

  Lytvynenko, M. (2021)

  Patients with comorbid pathology occupy leading positions in the practice of a doctor of any specialty especially in patients with HIV. Reproductive system is known to be the gateway for viruses. This fact could explain ...
• Peculiarities of structural changes in the liver, myocardium and kidneys of rats at different age under conditions of craniocerebral injury 

  Kholodkova, O.; Prus, R.; Sadovska, Y.; Horiuk, I.; Ternovyi, D. (2017)

  Abstract Morphological changes in the liver, kidneys and myocardium of mature and immature rats were studied 1 hour after mild craniocerebral injury. Clear changes in the type of microcirculatory disorders were found in ...
• Influence of platelet-enriched plasma on the morpho-functional state of liver in rats with induced non-alcoholic steatohepatitis and dyslipidemia 

  Appelhans, O.; Maznichenko, I.; Kasatkin, O.; Hussein, Abdulla; Biriuk, M.; Romak, O. (2020)

  Non-alcoholic steatohepatitis (NASH) is a consequence of the progression of nonalcoholic fatty liver disease (NAFLD), which can lead to cirrhosis or hepatocellular insufficiency. NAFLD is a predictor of cardiovascular ...
• Effect of the new dental elixir on the condition of rats’ periodontal tissues with simulated metabolic syndrome 

  Kravchenko, L. S.; Appelhans, O. L.; Polyakov, A. Ye.; Pasechnik, O. V.; Shcherbakov, S. V.; Кравченко, Л. С.; Аппельханс, О. Л.; Поляков, А. Є.; Пасечник, О. В.; Щербаков, С. В. (2020)

  Biochemical changes in the blood serum, liver and gingival tissue were examined during simulation of the metabolic syndrome of alimentary genesis in experiment on 28 white male rats of reproductive age with an average ...
• Polymorphism of SMAD7 (RS4939827) and EIF3H (RS16892766) genes as a criterium of fibrosis progression rate in patients with chronic hepatitis С and В 

  Appelhans, O. L.; Usychenko, K. M.; Bazhora, Yu. I.; Usychenko, O. M.; Аппельханс, О. Л.; Усиченко, К. М.; Бажора, Ю. І.; Усиченко, О. М. (2020)

  The purpose of the study was to assess the possibility of the relationship between the gene polymorphism of SMAD family member 7 (SMAD7C> T), the eukaryotic translation initiation factor (eIF3hC> A) and the degree of liver ...
• Effectiveness of the platelet-rich plasma application at different simulation periods of degenerative disc disease in rats 

  Zaporozhan, V. M.; Appelhans, O. L.; Tsyurupa, O. V.; Запорожан, В. М.; Аппельханс, О. Л.; Цюрупа, О. В.; Запорожан, В. Н.; Аппельханс, Е. Л.; Цюрупа, А. В. (2020)

  The article describes the study of the platelet-rich plasma application effectiveness for tissue regeneration of intervertebral discs in rats with simulated degenerative disk disease of the caudal vertebrae for 60 and 90 ...
• Indices of the cell cycle in the thyroid gland after thermal burns of the skin when using solutions of lactoprotein with sorbitol or HAES-LX 5 % 

  Tiron, O. I.; Appelhans, O. L.; Gunas, V. I.; Chereshniuk, I. L.; Lysenko, D. A.; Тірон, О. І.; Аппельханс, О. Л.; Гунас, В. І.; Черешнюк, І. Л.; Лисенко, Д. А.; Тирон, О. И.; Аппельханс, Е. Л.; Гунас, В. И.; Черешнюк, И. Л.; Лысенко, Д. А. (2020)

  The DNA content in the nuclei of thyroid cells of 90 white male rats on the background of skin burns of 2-3 degrees (with a lesion area of 21-23 % of the body surface) and the introduction of solutions of lactoprotein ...
• Effects of silver nanoparticles on pentylenetetrazol-induced kindled seizures in rats 

  Pervak, M. P.; Первак, М. П.; Первак, М. П. (2019)

  Silver nanoparticles are used for delivering neurotropic agents to brain, increasing the bioavailability of insoluble drugs as well as for brain tumours treatment. Their effects upon brain excitability, especially under ...
• Intrahepatic ultrasound-mediated gene delivery 

  Toporova, O. K.; Irodov, D. M.; Bubnov, R. V.; Kholodkova, O. L.; Gulko, T. P.; Ruban, T. P.; Morgunov, P. V.; Kordium, V. A. (2013)

  Transient ultrasound-induced increase in permeability of cell membrane and in some cases may enhance gene transfer. The objective of this work is to evaluate transfection efficiency and safety for intrahepatic gene delivery ...
• Implementation and analysis of Babesia immunoassay testing 

  Pokhil, S. I.; Bondarenko, A. V.; Bocharova, T. V.; Lepilina, K. M.; Lytvynenko, M. V.; Gargin, V. V. (2020)

  Lifelong withdrawal from the donor population of those who have been diagnosed with babesiosis must be used for transmission prevention. The aim of the study was a detection of Babesia antibodies level with the usage of ...
• Clinical and morphological features of combined hyperplastic diseases of the uterus against the background of adenomyosis 

  Rozhkovskaya, N. M.; Sitnikova, V. O.; Sivyi, S. M.; Lomakina, I. S. (2020)

  To determine clinical and morphological features of combined uterine hyperplastic diseases in premenopausal women at the background of adenomyosis, 62 patients operated on for chronic abnormal uterine bleeding were examined. ...
• The role of steroid receptors in the pathogenesis of adenomyosis in the presence of concomitant endometrial pathology in postmenopause 

  Honcharenko, G. Y. (, 2019)

  Determining the pathogenesis of adenomyosis in postmenopausal women is promising, as it will allow a more thorough study of the mechanisms of hormonal changes and resolve issues related to adenomyosis in women of ...

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