Динаміка психічного компонента якості життя у хворих на стабільну стенокардію напруження під впливом комбінованої гіполіпідемічної терапії

Abstract

Мета дослідження – вивчення особливостей впливу комбінованої ліпідокоригувальної терапії на показники психічного здоров’я ЯЖ у хворих на стабільну стенокардію.

According to current recommendations, lipid-lowering therapy is considered as base for treatment of atherosclerosis. Statins are recognized leaders in lipid-lowering effects, however their impact on high-density lipoproteins is insignificant. Fibrates, on the contrary, have a more positive impact on this factor, as well as on triglycerides, for which reason it seems reasonable to use a combination of statins and fibrates. This combination is rarely used in medical practice though for fear of increased side effects and reduced quality of life in the patients. The research objective — is to study the impact of the combination lipid-lowering therapy on mental health indicators of the quality of life in patients with stable angina pectoris. Мaterials and methods. The study involved 64 patients with stable angina, mean age (58.52± ±1.53) years. Group I (n=32) received a standard set of medications for patients with stable angina acompanied by atorvastatin 20 mg daily; group ІІ received atorvastatin in a reduced dose of 10 mg per day and fenofibrate in a dose of 145 mg per day. The patients subjectively assessed their condition using the MOS SF-36 questionnaire.