Антимікробні властивості нових координаційних сполук металів з лимонною кислотою

Abstract

Координационные соединения металлов — кобальта, германия, олова с лимонной кислотой подавляли рост штаммов Staphylococcus aureus, обладающих различным уровнем антибиотикорезистентности. Кобальтсодержащие соединения проявляли большую антимикробную активность.

Wide application of antibiotics in medicine is accompanied with spreading antibioticresistent strains of staphylococcus. That is why there is conducted a constant search for new effective anti-staphylococcal medicines. Purpose of research — studying anti-staphylococcal activity of the coordination compounds of metals — cobalt, germanium, tin with the citric acid on staphylococcus strains: Staphylococcus aureus ATSS 25923, Staphylococcus aureus 2781, Staphylococcus aureus Cunda. Materials and methods. For studying sensitivity it was used a method of serial dilution in the fluid culture — the minimal concentrations of compounds were determined. Measuring turbidity of bacterial suspensions was conducted on densitometer, and value of optical density of suspension were interpreted by Mac-Farland turbidity unit (McF). Results of research. The examined compounds supressed growth of strains of Staphylococcus aureus, possessing a different level of antibiotic resistance. The cobalt-containing compound revealed high antimicrobial activity