Use of formation of ionic associations with azo dyes in the express analysis of vascular-type calcium channel blockers (using the example of amlodipine)

Abstract

In modern pharmaceutical practice, there is a growing need for fast, simple, and cost-effective methods for quality control of medicinal products. This is especially true for mass-marketed drugs, in particular vascular-type calcium channel blockers, which include amlodipine. Despite the widespread use of highly efficient instrumental analysis methods, their application in express control conditions is limited due to the high cost of equipment and the complexity of sample preparation. The aim of the study was to theoretically and experimentally substantiate the possibility of using reactions of formation of ionic associates of amlodipine with azo dyes for rapid analysis of drugs.